25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and -Cell Function Relative to Insulin Sensitivity in Black and White Youth

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25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and β-Cell Function Relative to Insulin Sensitivity in Black and White Youth

OBJECTIVE To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had existing data on hyperinsulinemic-euglyc...

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25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care 2012;35:627–633

D concentrations and in vivo insulin sensitivity and b-cell function relative to insulin sensitivity in black and white youth. In the print version of the article listed above, in the " Biochemical Measurements " section, the sentence " The intrassay and interassay coefficients of variation were 8 ng/mL and 10 ng/mL, respectively " should read as follows: " The intraassay and interassay coeffic...

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25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and b-Cell Function Relative to Insulin Sensitivity in Black andWhite Youth

RESULTSdA total of 183 research volunteers (mean6 SD; age, 12.66 2.2 years; 98 white, 98 male, 92 obese) were studied. Analysis of HbA1c, fasting glucose and insulin, insulin sensitivity, and DI across quartiles of plasma 25(OH)D revealed no differences among whites. In blacks, the observed significance of higher insulin sensitivity and DI in the highest quartile of 25(OH)D disappeared after ad...

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Measuring β-Cell Function Relative to Insulin Sensitivity in Youth

OBJECTIVE To compare β-cell function relative to insulin sensitivity, disposition index (DI), calculated from two clamps (2cDI, insulin sensitivity from the hyperinsulinemic-euglycemic clamp and first-phase insulin from the hyperglycemic clamp) with the DI calculated from the hyperglycemic clamp alone (hcDI). RESEARCH DESIGN AND METHODS Complete data from hyperglycemic and hyperinsulinemic-eu...

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Insulin sensitivity and blood pressure in black and white children.

Although insulin sensitivity is correlated with high blood pressure in adults, it is unclear whether such a relationship exists in children across ethnic groups. Therefore, the aims of the study were to establish (1) if body composition and insulin sensitivity were related to blood pressure in children, and (2) if any differences in blood pressure between white and black children were explained...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2012

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc11-1825